Protein Mutations
As large-scale re-sequencing of genomes reveals several supramolecular mutations, particularly in human cancer tissues, prediction of their seemingly purposeful impact becomes vital sensible goal. Here, we tend to introduce a replacement purposeful impact score (FIS) for organic compound residue changes victimization biological process conservation patterns. the knowledge in these patterns comes from aligned families and sub-families of sequence homologs at intervals and between species victimization combinatorial entropy formalism. The score performs well on an outsized set of human supramolecular mutations in separating disease-associated variants , assumed to be powerfully purposeful, from common polymorphisms, assumed to be feeble purposeful . In cancer, victimization return, multiplicity and annotation for ∼10 000 mutations within the COSMIC info, the tactic will well in distribution higher scores to a lot of seemingly purposeful mutations‘drivers’. To guide experimental prioritization, we have a tendency to report an inventory of regarding a thousand high human cancer genes ofttimes mutated in one or a lot of cancer varieties hierarchical by seemingly purposeful impact; and, a further a thousand candidate cancer genes with rare however seemingly purposeful mutations. additionally, we have a tendency to estimate that a minimum of five-hitter of cancer-relevant mutations involve switch of perform, instead of merely loss or gain of perform.
- Protein 3D Structure
- Isoelectric Point
- Genome
Related Conference of Protein Mutations
16th International Conference on Tissue Science and Regenerative Medicine
15th International Conference on Biofuels and Bioenergy
Protein Mutations Conference Speakers
Recommended Sessions
- Clinical Enzymology
- Computational Enzymology
- Biochemistry of Enzymes
- Biopolymers in Enzymology
- Case Study on Enzymology
- Chromatography
- Enzyme Kinetics
- Enzymes as Drug Targets
- Enzymes in Food Technology
- Enzymes in Pharma Biotechnology
- Industrial Enzymology
- Mass Spectroscopy
- Metalloenzymes
- Micellar Enzymology
- Peptide Chemistry
- Protein crystallography
- Protein Engineering
- Protein Mutations
- Protein Post-Translational Modifications
- Protein Synthesis
- Proteolysis
- Proteomics
- Psychrophilic Enzymes
Related Journals
Are you interested in
- Regenerative Medicine Market - Tissue Science 2024 (Italy)
- .Bone Tissue Engineering - Tissue Science 2024 (Italy)
- Advances in analytical techniques - DRUG CHEMISTRY CONF 2024 (UK)
- Adverse drug reactions - DRUG CHEMISTRY CONF 2024 (UK)
- Anti-Aging, Regenerative and functional Medicine - Tissue Science 2024 (Italy)
- Applications of Tissue Engineering - Tissue Science 2024 (Italy)
- Artificial intelligence in drug discovery - DRUG CHEMISTRY CONF 2024 (UK)
- Artificial Organs - Tissue Science 2024 (Italy)
- Bio Banking - Tissue Science 2024 (Italy)
- Biofabrication and 3D Printing - Tissue Science 2024 (Italy)
- Biomaterials and Bioengineering - Tissue Science 2024 (Italy)
- Biomedical Engineering Techniques - Tissue Science 2024 (Italy)
- Biotechnology - BIOTECH ASIA PACIFIC 2024 (Spain)
- Biotechnology and nanotechnology in stem cells - Tissue Science 2024 (Italy)
- Cardiovascular Regeneration: - Tissue Science 2024 (Italy)
- Cell and Organ Regeneration - Tissue Science 2024 (Italy)
- Cellular and gene Therapies - Tissue Science 2024 (Italy)
- Challenges in translating research to practice - DRUG CHEMISTRY CONF 2024 (UK)
- Clinical Applications and Translational Research: - Tissue Science 2024 (Italy)
- Clinical trial design and compliance - DRUG CHEMISTRY CONF 2024 (UK)
- Dental and Craniofacial Regeneration: - Tissue Science 2024 (Italy)
- Drug pricing and affordability - DRUG CHEMISTRY CONF 2024 (UK)
- Emerging Technologies and Future Trends - Tissue Science 2024 (Italy)
- Ethical considerations in drug development - DRUG CHEMISTRY CONF 2024 (UK)
- Gene and Immunotherapy - Tissue Science 2024 (Italy)
- Global Perspectives and Healthcare Equity: - Tissue Science 2024 (Italy)
- Immunomodulation and Tissue Compatibility - Tissue Science 2024 (Italy)
- Medicinal chemistry approaches for specific diseases - DRUG CHEMISTRY CONF 2024 (UK)
- Musculoskeletal Regeneration: - Tissue Science 2024 (Italy)
- Nanotechnology in drug delivery - DRUG CHEMISTRY CONF 2024 (UK)
- Natural products in drug discovery - DRUG CHEMISTRY CONF 2024 (UK)
- Neuro regeneration and Brain Repair: - Tissue Science 2024 (Italy)
- Pharmaceutical Biotechnology - BIOTECH ASIA PACIFIC 2024 (Spain)
- Pharmaceutical Biotechnology - BIOTECH ASIA PACIFIC 2024 (Spain)
- Preclinical and clinical studies - DRUG CHEMISTRY CONF 2024 (UK)
- Rational drug design - DRUG CHEMISTRY CONF 2024 (UK)
- Regenerative Rehabilitation - Tissue Science 2024 (Italy)
- Soft Tissue Replacement - Tissue Science 2024 (Italy)
- Stem Cell Bioprocessing - Tissue Science 2024 (Italy)
- Stem Cell Treatments - Tissue Science 2024 (Italy)
- Stem Cells and Regenerative Therapies: - Tissue Science 2024 (Italy)
- test - DRUG CHEMISTRY CONF 2024 (UK)
- Tissue Engineering - Tissue Science 2024 (Italy)
- Tissue Engineering and Biomaterials - Tissue Science 2024 (Italy)
- Tissue Repair and Regeneration - Tissue Science 2024 (Italy)
- Workshops and Interactive Sessions: - Tissue Science 2024 (Italy)