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Min Kyu Kwak


Min Kyu Kwak

Seoul National University, South Korea

Biography

Min-Kyu Kwak has his expertise in Metabolic Regulation driven by physiological roles of methylglyoxal biosynthesis/degradation enzymes. His model based on methylglyoxal production/detoxification hierarchy suggests different metabolic control systems between prokaryotes and eukaryotes. Because his findings provide a basis for understanding cell growth, viability, and differentiation to elevate the intracellular metabolites including methylglyoxal, glutathione, and reactive oxygen species, this should be of interest to scientists who are interested in the methylglyoxal metabolism and it’s regulating enzymes in cells. His research is also to elucidate the mechanism of energy transfer which is a fundamental mechanism in life. Energy transfer mechanisms are mediated by electrons and photons. He aims to elucidate the function and structure of intermediate products, enzymes and genes involved in cell change down to the level of electrons and photons; mechanisms of “polymorphic changes of Candida albicans, developmental processes of Dictyostelium discoideum, and sporulation of Bacillus subtilis regarding electron transfer.

Abstract

Abstract : Candida albicans glutathione reductase downregulates Efg1-mediated cyclic AMP/protein kinase-A pathway and leads to defective hyphal growth and virulence upon decreased cellular methylglyoxal content accompanied by activating alcohol dehydrogenase and glycolytic enzymes